Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Association of thrombelastographic parameters with post-stenting ischemic events
First author：Wang, Bo
Corresponding author：Zhong-Rong Miao
essential_information
2017-02-01
Published articles
Journal：Journal of Neurointerventional Surgery
Publication type: Original Research
IF(IF): 5.836
PMID: 26041100 Link To Pubmed Full text Download
Background And Purpose
Method
Patients in whom stenting was performed for extracranial or intracranial artery stenosis (70-99%) were recruited into the study. Blood samples were obtained for TEG to assess platelet function before stenting. The primary endpoint was ischemic stroke or transient ischemic attack in the territory of the stented artery.
Conclusion
Our study suggests that TEG parameters MAADP and ADP% are associated with subsequent ischemic events in patients with extracranial or intracranial stents.
Main results
A total of 218 patients were included in the study. During a mean follow-up period of 132 days (range 98-226 days), 18 (8.3%) primary endpoint events were recorded. Compared with patients without ischemic events, the ADP-induced platelet-fibrin clot strength (MAADP) was significantly higher (41.57±15.10 vs 33.50±13.86, p=0.020) and the ADP inhibition rate (ADP%) was significantly lower in patients with ischemic events (39.54±23.15 vs 55.29±24.43, p=0.009). Multivariate analysis identified MAADP and ADP% as significant independent predictors of subsequent ischemic events with HRs of 1.036 and 0.965, respectively. From receiver operating characteristic curve analysis, MAADP >49.95 mm had the best predictive value of ischemic events.