国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Diagnostic accuracy of routine blood examinations and CSF lactate level for post-neurosurgical bacterial meningitis
第一作者：Zhang, Yang
通讯作者：Zhang, Liwei
基本信息
- 负责人：Zhang, Yang
- 数据来源： OTHERS
- 论文编号：OTHERS20190502
- 发表时间：2017-06-01
2017-06-01
已发表文章
发表杂志：International Journal of Infectious Diseases
发表类型: Research Article
影响因子(IF): 3.623
PMID: 28392319 Pubmed原文链接 全文下载
主要研究背景及目的
方法
The diagnostic accuracies of routine blood examinations and CSF lactate level to distinguish between PAM and PBM were evaluated with the values of the Area Under the Curve of the Receiver Operating Characteristic (AUC-ROC) by retrospectively analyzing the datasets of post-neurosurgical patients in the clinical information databases.
结论
The PBM diagnostic accuracy of routine blood examinations was relatively low, whereas the accuracy of CSF lactate level was high. Some variables that are involved in the incidence of PBM can also affect the diagnostic accuracy for PBM. Taking into account the effects of these variables significantly improves the diagnostic accuracies of routine blood examinations and CSF lactate level.
主要结果
The diagnostic accuracy of routine blood examinations was relatively low (AUC-ROC<0.7). The CSF lactate level achieved rather high diagnostic accuracy (AUC-ROC=0.891; CI 95%, 0.852-0.922). The variables of patient age, operation duration, surgical diagnosis and postoperative days (the interval days between the neurosurgery and examinations) were shown to affect the diagnostic accuracy of these examinations. The variables were integrated with routine blood examinations and CSF lactate level by Fisher discriminant analysis to improve their diagnostic accuracy. As a result, the diagnostic accuracy of blood examinations and CSF lactate level was significantly improved with an AUC-ROC value=0.760 (CI 95%, 0.737-0.782) and 0.921 (CI 95%, 0.887-0.948) respectively.