Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
The association between high on-treatment platelet reactivity and early recurrence of ischemic events after minor stroke or TIA
First author：Rao, Zilong Zheng, Huaguang Wang, Fei
Corresponding author：Wang, Yilong Cao, Yibin
essential_information
- Person in charge：Rao, Zilong Zheng, Huaguang Wang, Fei
- Data Sources： OTHERS
- Number of papers：OTHERS20190535
- Published time：2017-08-01
2017-08-01
Published articles
Journal：Neurol Res
Publication type: Research Article
IF(IF): 2.448
PMID: 28398139 Link To Pubmed Full text Download
Background And Purpose
Method
From January 2014 to September 2014, a single center continuously enrolled patients with minor ischemic stroke or high-risk TIA and gave them antiplatelet therapy consisting of aspirin with clopidogrel. HTPR was assessed by TEG after 7 days of antiplatelet therapy and detected CYP2C19 genotype. The incidence of recurrent ischemic events was assessed 3 months after onset. The incidence of recurrent ischemic events was compared between the HTPR and NTPR groups with the Kaplan-Meier method, and multivariate Cox proportional hazards models were used to determine the risk factors associated with recurrent ischemic events.
Conclusion
In patients with minor stroke or TIA, the prevalence of HTPR was 22.7%, and HTPR was independently associated with recurrent ischemic events.
Main results
We enrolled 278 eligible patients with minor ischemic stroke or high-risk TIA. Through TEG testing, patients with HTPR were 22.7%, and carriers were not associated with HTPR to ADP by TEG-ADP(%) (p = 0.193). A total of 265 patients completed 3 months of follow-up, and Kaplan-Meier analysis showed that patients with HTPR had a higher percentage of recurrent ischemic events compared with patients with NTPR (p = 0.002). In multivariate Cox proportional hazards models, history of ischemic stroke or TIA (HR 4.45, 95% CI 1.77-11.16, p = 0.001) and HTPR (HR 3.34, 95% CI 1.41-7.91, p = 0.006) was independently associated with recurrent ischemic events.