Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Adolescents with moyamoya disease: clinical features, surgical treatment and long-term outcomes.
First author：Zhao, Meng
Corresponding author：Zhao, Jizong
essential_information
- Person in charge：Zhao, Meng
- Data Sources： OTHERS
- Number of papers：OTHERS20190543
- Published time：2017-11-01
2017-11-01
Published articles
Journal：Acta Neurochir (Wien)
Publication type: Original Article
IF(IF): 1.834
PMID: 28791519 Link To Pubmed Full text Download
Background And Purpose
Method
We reviewed consecutive patients with moyamoya vasculopathy who were admitted to our hospital from 2009 to 2015 to identify adolescent patients with moyamoya disease. Clinical features, surgical treatment and long-term outcomes were analyzed. Follow-up was performed by face-to-face or structured telephone interviews. Outcome measures were future stroke events. We performed univariate and multivariate time-to-event analyses to identify risk factors associated with future stroke events.
Conclusion
Our results demonstrate that direct/combined bypass can be more effective in preventing future strokes than indirect bypass in adolescent patients with moyamoya disease.
Main results
A total of 95 adolescent patients with moyamoya disease (age at onset, 13.1 ± 2.3 years) were included in this study. During follow-up, 12 patients (12.6%) had stroke events. We found that the patients who underwent direct/combined bypass had a significantly lower risk of future strokes [hazard ratio (HR), 0.16; 95% confidence interval (CI), 0.03-0.74; P = 0.019] compared to patients who underwent indirect bypass.