Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Factors associated with severity of leukoaraiosis in first-ever lacunar stroke and atherosclerotic ischemic stroke patients
First author：Zhang, Changqing
Corresponding author：Wang, Yongjun
essential_information
- Person in charge：Zhang, Changqing
- Data Sources： CICAS
- Number of papers：CICAS20150102
- Published time：2014-10-03
2014-10-03
Published articles
Journal：J Stroke Cerebrovasc Dis
Publication type: Original Contributions
IF(IF): 1.669
PMID:
Background And Purpose
BACKGROUND: Leukoaraiosis (LA) is an indicator of small vessel disease, but little is known about the relationship between the severity of LA and etiologic subtype of ischemic stroke. Our study aimed to investigate the factors associated with the severity of LA and the relationship between the severity of LA and etiologic subtype of ischemic stroke. METHODS: A total of 791 patients with first-ever ischemic stroke within 7 days were enrolled in our study. We evaluated cranial magnetic resonance imagings including severity of LA in periventricular and deep white matter, severity of silent lacunar infarcts (SLIs), etiologic subtype of ischemic stroke, and topographic patterns of acute cerebral infarcts. Severity of LA was graded as grade 0 when Fazekas scores = 0, grade 1 when Fazekas scores ranged from 1 to 2, and grade 2 when Fazekas scores were greater than or equal to 3. Multivariable ordinal logistic regression was used to analyze the factors associated with the severity of LA.