国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

A comparison of clinicopathological features and surgical outcomes between pediatric skull base and non-skull base meningiomas

第一作者：Li, Zhicen Li, Hao

通讯作者：Cao, Yong

Clinical features Outcomes Pediatric meningiomas S

基本信息

2017-04-01

已发表文章

发表杂志：Childs Nerv Syst

发表类型: Original Paper

影响因子(IF): 1.327

PMID: 27796552 Pubmed原文链接 全文下载

主要研究背景及目的

方法

We retrospectively analyzed a total of 140 cases of pediatric meningiomas surgically treated in our department from January 2005 to July 2015 and compared the clinicopathological characteristics and surgical outcomes between skull base and non-skull base meningiomas.

结论

Pediatric skull base and non-skull base meningiomas are similar in sex distribution and high-grade meningioma occurrence rate. In comparison with non-skull base ones, pediatric skull base meningiomas occur at elder age and are smaller in size and they are more likely to be incompletely resected. Gross total resection and early treatment are recommended to prolong PFS of pediatric patients.

主要结果

Of all the pediatric meningiomas, 50 (35.8 %) were located at the skull base and 90 (64.2 %) were located at the non-skull base. Skull base and non-skull base meningiomas had a similar sex distribution (male/female = 1:1 in skull base meningiomas and male/female = 1.5:1 in non-skull base meningiomas) (P = 0.288) and high-grade meningioma occurrence rate (P = 0.569). In addition, the mean age of non-skull base meningiomas was 12.5 years which was younger than that of skull base meningiomas (14.2 years) (P = 0.019), and the preoperative tumor size was smaller in skull base (mean size = 4.7 cm in skull base meningiomas and mean size = 5.7 cm in non-skull base meningiomas) (P = 0.020). Gross total resection was achieved in 64 non-skull base patients (73.9 %) and 26 skull base patients (52 %) (P = 0.046). Patients with gross total resection had better progression free survival (PFS) than those with subtotal resection.