Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Does Right-Sided Language Lateralization on BOLD-fMRI, Affect Postoperative Language Outcome for AVM Patients?
First author：Liu, Zhi
Corresponding author：Wang, Shuo
essential_information
2017-09-01
Published articles
Journal：Turkish Neurosurgery
Publication type: Original Investigation
IF(IF): 1.003
PMID: 27509456 Link To Pubmed Full text Download
Background And Purpose
Method
Clinical and imaging data of 43 right-handed AVM patients who underwent preoperative fMRI were retrospectively reviewed. All lesions involved the language cortex, with the Broca area involved in 13 patients and the Wernicke area involved in 30 patients. Lateralization indices (LI) of BOLD signal activations were calculated to determine language lateralization. All patients underwent craniotomy and total resection. Western aphasia battery (WAB) was used to evaluate language functions preoperatively, 1-2 weeks after surgery and 6-30 months after surgery.
Conclusion
Although right-sided lateralization on fMRI might suggest language cortex reorganization, it is not a factor predicting better postoperative language outcome for AVM patients.
Main results
On preoperative fMRI, right-sided lateralization was observed in 18 patients (41.9%, R Group), including 3 with rightsided lateralization in the Broca area alone, 14 in the Wernicke area alone, and 1 in both areas. The other 25 patients were non-rightsided lateralized (NR Group). One week after surgery, 7 patients in the R Group (38.9%) and 11 patients in the NR Group (44.0%) had language function deterioration, and no significant difference was found (p=0.983). At long-term follow-up, 3 patients in the R Group (16.7%) and 4 patients in the NR Group (16.0%) still had aphasia, and no significant difference was observed (p=1.000).