国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

De Novo Design of alpha-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery

第一作者：Wang Chao,Zhao Lei,Xia Shuai,Zhang Tianhong

通讯作者：Zhong Wu,Jiang Shibo,Liu Keliang

alpha-Helical Lipopeptides

基本信息

2018-09-07

已发表文章

发表杂志：J. Med. Chem.

发表类型: Research Article

影响因子(IF): 6.054

PMID: 30192544 Pubmed原文链接 全文下载

主要研究背景及目的

方法

Here, we present the construction of a series of lipopeptides composed of a de novo heptad repeat sequence-based α-helical peptide plus a hydrocarbon tail. Promisingly, the constructs adopted stable α-helical conformations and exhibited relatively broad-spectrum antiviral activities against Middle East respiratory syndrome coronavirus (MERS-CoV) and influenza A viruses (IAVs).

结论

Together, these findings reveal a new strategy for relatively broad-spectrum antiviral drug discovery by relying on the tunability of the α-helical coiled-coil domains present in all class I fusion proteins and the amphiphilic nature of the individual helices from this multi-helix motif.

主要结果