Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Decreased level of irisin, a skeletal muscle cell-derived myokine, is associated with post-stroke depression in the ischemic stroke population
First author：Tu Wen-Jun,Qiu Han-Cheng
Corresponding author：Zhao Ji-Zong
essential_information
- Person in charge：Tu Wen-Jun,Qiu Han-Cheng
- Data Sources： OTHERS
- Number of papers：OTHERS20190620
- Published time：2018-05-02
2018-05-02
Published articles
Journal：J Neuroinflammation
Publication type: Article
IF(IF): 5.7
PMID: 29720216 Link To Pubmed Full text Download
Background And Purpose
Method
The subjects were first-ever AIS patients who were hospitalized at three stroke centers during the period from January 2015 to December 2016. Neurological and neuropsychological evaluations were conducted at the 6-month follow-up. Serum irisin concentrations were measured by enzyme-linked immunosorbent assay (ELISA).
Conclusion
The data suggested that reduced serum levels of irisin were powerful biological markers of risk of developing PSD even after adjustment by variables. Further studies are necessary to confirm this association, which may open the way to the proposal of new therapeutic options.
Main results
During the study period, 1205 patients were included in the analysis. There were 370 patients (30.7%) classified as depression. The depression distribution across the irisin quartiles ranged between 49.8% (first quartile) and 9.9% (fourth quartile). In the patients with depression, serum irisin levels were lower compared with those in patients without depression (P?