国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Association between impaired renal function and stroke outcome in patients with versus without atrial fibrillation

第一作者：Pan Y

通讯作者：He Y

atrial fibrillation estimated glomerular filtratio

基本信息

  • 负责人：Pan Y
  • 数据来源： OTHERS
  • 论文编号：OTHERS20190631
  • 发表时间：2018-08-01

2018-08-01

已发表文章

发表杂志：Eur J Neurol.

发表类型: Original Article

影响因子(IF): 4.387

PMID: 29512928 Pubmed原文链接 全文下载

主要研究背景及目的

方法

Patients with ischaemic stroke in the China National Stroke Registry were included. Low estimated glomerular filtration rate (eGFR) on admission was defined as <60 ml/min/1.73 m2 . Outcomes included stroke recurrence, death, poor outcome defined as 3-6 on the modified Rankin Scale (mRS) and ordinal mRS at 12 months.

结论

Stroke patients with lower eGFR had more presence of AF. The associations of low eGFR with risk of poor prognosis in stroke patients with AF were stronger than those without AF.

主要结果

Of 9154 patients included, 1143 (12.5%) patients had a low eGFR. Patients with a low eGFR had more presence of AF compared with those with an eGFR of ≥90 ml/min/1.73 m2 [21.5% vs. 6.9%; odds ratio (OR) 1.77, 95% confidence interval (CI) 1.43-2.20]. An interaction of eGFR category by AF was observed for poor outcome and ordinal mRS (P for interaction = 0.04 and 0.002). In patients with AF, the OR with 95% CI of low eGFR was 1.86 (1.19-2.92) for stroke recurrence, 2.87 (1.82-4.52) for death, 1.83 (1.09-3.05) for poor outcome and 2.20 (1.52-3.18) for ordinal mRS. In patients without AF, low eGFR was only associated with death and ordinal mRS (OR 1.61, 95% CI 1.28-2.02; common OR 1.20, 95% CI 1.04-1.38; respectively).