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Role of EGFL7/EGFR-signaling pathway in migration and invasion of growth hormone-producing pituitary adenomas
First author：Liu Qian
Corresponding author：Zhang Yazhuo
essential_information
2018-08-01
Published articles
Journal：Sci China Life Sci
Publication type: Research Paper
IF(IF): 6.038
PMID: 29951953 Link To Pubmed Full text Download
Background And Purpose
Method
Herein, we observed that the expression level of EGFL7 and p-EGFR in invasive GHPA was much higher than that of non-invasive GHPA. The overexpression of EGFL7 was positively correlated with activation of EGFR (p-EGFR). Noticeably, EGFL7 knockdown significantly inhibited activation of EGFR signaling cascades, including p-ERGR, p-AKT and p-ERK.
Conclusion
In summary, our findings suggest that EGFL7 is a key factor for regulation of EGFR signaling pathway and plays an important role in migration and invasion of invasive GHPA.
Main results
Further studies showed that EGFL7 knockdown or pharmacological inhibition of EGFR-pathway, using EGFR inhibitor Tyrphostin AG-1478, significantly suppressed migration and invasion of GH3 and GT1-1 cells.