Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Analyses of Clinical Features and Investigations on Potential Mechanisms in Patients with Alzheimer's Disease and Olfactory Dysfunction
First author：Zuo Li-Jun
Corresponding author：Zhang Wei
essential_information
- Person in charge：Zuo Li-Jun
- Data Sources： OTHERS
- Number of papers：OTHERS20190661
- Published time：2018-10-30
2018-10-30
Published articles
Journal：J Alzheimers Dis
Publication type: Research Article
IF(IF): 4.472
PMID: 30347619 Link To Pubmed Full text Download
Background And Purpose
Method
We evaluated OD using the Hyposmia Rating Scale (HRS), classified patients into AD with OD (AD-OD) and AD with no OD (AD-NOD) groups, and detected the levels of free radicals and inflammatory factors, including hydroxyl radical (•OH), hydrogen peroxide (H2O2), nitric oxide, interleukin-1β, interleukin-6, tumor necrosis factor-α, and prostaglandin E2 in serum from AD patients.
Conclusion
AD-OD patients suffered from severe cognitive impairment in the domain of language. Oxidative stress might be correlated with AD-OD featured by the drastically increased •OH level in serum.
Main results
It was shown that the scores of the Mini-Mental State Examination, Animal Fluency Test, Boston Naming Test (BNT), and Auditory Verbal Learning Test-delayed recall were all significantly lower and the score of overall activity of daily living (ADL) and instrumental ADL were significantly higher in AD-OD group than those in AD-NOD group. Compared with AD-NOD group, •OH level in serum was prominently elevated, and H2O2 level was dramatically declined in AD-OD group. In the correlation analysis, HRS score was significantly and positively correlated with the score of BNT, and negatively correlated with •OH level in serum.