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Decompressive craniectomy protects against hippocampal edema and behavioral deficits at an early stage of a moderately controlled cortical impact brain injury model in adult male rats.
First author：Houa Zonggang, Zonggang
Corresponding author：Liu Baiyun, Baiyun
essential_information
- Person in charge：Houa Zonggang, Zonggang
- Data Sources： OTHERS
- Number of papers：OTHERS20190683
- Published time：2018-06-01
2018-06-01
Published articles
Journal：Behavioural Brain Research
Publication type: Article
IF(IF): 3.332
PMID: 29452194 Link To Pubmed
Background And Purpose
Method
In this study, we established a controlled cortical impact injury rat model to evaluate the therapeutic effect of DC treatment on behavioral deficits at 1 d, 2 d, 3 d and 7 d after TBI.
Conclusion
In conclusion, decompressive craniectomy, excepting for its life-saving effect, could also play a potential beneficial neuroprotective role on behavioral but not mood deficits at an early stage of moderate traumatic brain injury in rats. Copyright © 2018. Published by Elsevier B.V.
Main results
Our results showed that rats suffered significant behavioral and mood deficits after TBI compared to the control group, while decompressive craniectomy treatment could normalize MMP-9 expression levels and reduce hippocampal edema formation, stabilize the expression of Synapsin I, which was a potential indicator of maintaining the hippocampal synaptic function, thus counteracting behavioral but not mood decay in rats subjected to TBI.