国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
MEGF10, a Glioma Survival-Associated Molecular Signature, Predicts IDH Mutation Status
基本信息
- 负责人：Li Guanzhang, Guanzhang
- 数据来源： OTHERS
- 论文编号：OTHERS20190684
- 发表时间：2018-05-20
2018-05-20
已发表文章
主要研究背景及目的
方法
A package compiled under R language called Tspair was used as the main analytic tool to find potential probes that were significantly affected by IDH mutation.
结论
In a word, our results suggested that methylation level and mRNA expression of MEGF10 in glioma were not only correlated with IDH mutation but also associated with clinical outcome of patients, providing potential guide for future dissection of IDH role in glioma.
主要结果
As a result, we found one pair of probes, cg06940792 and cg26025891, which was capable of predicting IDH mutation status precisely. The hypermethylated probe was cg06940792, designed in the promoter region of MEGF10, while the hypomethylated probe was cg26025891, designed in the promoter region of PSTPIP1. Survival analysis proved that hypermethylation or low expression of MEGF10 indicated a favorable prognosis in 983 glioma samples. Moreover, gene ontology analysis demonstrated that MEGF10 was associated with cell migration, cell proliferation, and regulation of apoptosis in glioma. All findings above can be validated in three other independent cohorts