Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Symptomatic and silent cerebral infarction following surgical clipping of unruptured intracranial aneurysms: incidence, risk factors, and clinical outcome
First author：Li Maogui, Maogui
Corresponding author：Wang Shuo, Shuo
essential_information
- Person in charge：Li Maogui, Maogui
- Data Sources： OTHERS
- Number of papers：OTHERS20190697
- Published time：2018-04-01
2018-04-01
Published articles
Journal：Neurosurg Rev
Publication type: Article
IF(IF): 3.042
PMID: 28983720 Link To Pubmed Full text Download
Background And Purpose
Method
To determine the incidence, risk factors, and clinical outcome of postoperative CI, we retrospectively analyzed 388 consecutive patients undergoing clipping of UIAs between January 2012 and December 2015. We reviewed the pre- and postoperative computed tomography (CT) images of each patient. Postoperative CI was defined as a new parenchymal hypodensity in the vascular territory of treated artery. Patient-specific, aneurysm-specific, and operative variables were analyzed as potential risk factors. Functional outcome at discharge was assessed with the modified Rankin Scale (mRS).
Conclusion
In conclusion, the incidence of CI following clipping of UIAs was not low. Larger aneurysm size and history of hypertension were independent risk factors. Postoperative symptomatic stroke correlated with an extremely high risk of disability. Silent CI was seemingly nondisabling, but the possible cognitive consequence is pending.
Main results
Postoperative CI was found in 49 (12.6%) patients, 29 of whom manifested neurological deficits. The incidences of symptomatic stroke and silent CI were 7.5 and 5.2%, respectively. Multivariate analysis showed that larger aneurysm size and history of hypertension were significantly associated with CI. Disability (mRS > 2) rate was 42.9% among patients with CI, which was substantially higher than that among patients without (0.9%).