国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Association of hemoglobin glycation index with outcomes of acute ischemic stroke in type 2 diabetic patients

第一作者：Pan Yuesong, Yuesong

通讯作者：Wang Yilong, He Yan, Yan

Diabetes mellitus hemoglobin A1c ischemic stroke o

基本信息

2018-07-01

已发表文章

发表杂志：Neurol Res

发表类型: Article

影响因子(IF): 2.448

PMID: 29560815 Pubmed原文链接 全文下载

主要研究背景及目的

方法

Data were derived from the Abnormal Glucose Regulation in Patients with Acute Stroke across China (ACROSS-China) registry. Diabetic patients with ischemic stroke were included. HGI was calculated by subtracting the predicted HbA1c based on fasting plasma glucose from the observed HbA1c, and then classified into three groups by the tertiles: low HGI (<-0.62), moderate HGI (-0.62 to 0.35) and high HGI (≥0.36). Outcomes included stroke recurrence, all-cause death and poor outcome at 12 months.

结论

Both low HGI and high HGI was associated with an increased risk of poor prognosis in diabetic patients with ischemic stroke, compared with moderate HGI.

主要结果

A total of 976 diabetic patients were included. Low HGI was associated with an increased risk of stroke recurrence and poor outcome (adj.hazard ratio 1.53, 95% confidence intervals (CIs) 1.11-2.12, p = 0.01; and adj.odds ratio 1.64, 95% CI 1.13-2.38, p = 0.01, respectively), and high HGI was associated with an increased risk of poor outcome (adj.odds ratio 1.54, 95% CI 1.06-2.24, p = 0.02), compared with moderate HGI. We found a U-shaped association between HGI and the prognosis.