国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Encephaloduroateriosynangiosis versus conservative treatment for patients with moyamoya disease at late Suzuki stage

第一作者：Ge Peicong, Peicong

通讯作者：Zhao Jizong, Jizong

Conservative treatment Encephaloduroateriosynangio

基本信息

2018-04-01

已发表文章

发表杂志：J Clin Neurosci

发表类型: Article

影响因子(IF): 1.961

PMID: 29366619 Pubmed原文链接 全文下载

主要研究背景及目的

方法

We retrospectively reviewed 64 patients (128 hemispheres) with moyamoya disease at late Suzuki Stage at Beijing Tiantan Hospital. Clinical features, radiologic findings, and outcomes were analyzed.

结论

Although indirect bypass surgery was shown to be effective in improving the cerebral perfusion in patients with MMD at late Suzuki stage, it failed to reduce the risk of recurrent stroke compared to conservative treatment. Further study is needed to determine whether direct bypass surgery is effective in MMD patients at late Suzuki stage.

主要结果

The mean age at diagnosis was 29.0 ± 14.9 years. The distribution of the initial Suzuki stage of MMD was as follows: stage 4, n = 75; stage 5, n = 46; stage 6, n = 7, PCA involvement was observed in 4 (37.5%) hemispheres. The incidence of postoperative stroke was 6.7%. During the average follow-up of 46.9 ± 21.1 months, including postoperative and follow-up strokes, seven of 75 (9.3%) conservatively treated hemispheres and 10 of 87 (10.1%) surgically treated patients experienced a stroke event there was not statistically significant in the Kaplan-Meier curve of stroke incidence between the surgical group and conservative group (log-rank test, p = .848). However, the rate of perfusion improvement in indirect bypass surgically treated patients was higher than in those conservative treated patients 3 months after discharge (p < .05).