Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Giant cavernous malformations: A single center experience and literature review
First author：Wang Chengjun, Chengjun
Corresponding author：Zhao Jizong, Jizong
essential_information
- Person in charge：Wang Chengjun, Chengjun
- Data Sources： OTHERS
- Number of papers：OTHERS20190766
- Published time：2018-10-01
2018-10-01
Published articles
Journal：J Clin Neurosci
Publication type: Article
IF(IF): 1.961
PMID: 29983331 Link To Pubmed Full text Download
Background And Purpose
Method
From January of 2003 to December 2016, nine GCM patients who underwent neurosurgical treatment at Beijing Tiantan Hospital were chosen for analysis and their records were reviewed. We also performed an exhaustive literature search and identified all previously reported GCMs.
Conclusion
GCM is a rare subgroup of vascular malformations; it is more prone to occur in children and adolescents. Microsurgical resection should be the treatment of choice for GCMs, and despite their giant size, excellent surgical outcomes after total removal could be achieved.
Main results
The study population consisted of three males and six females (mean age, 25.1 years). The mean diameter of the malformations was 6.7 cm (range, 6.0-8.4 cm). The most common clinical manifestations were the symptoms caused by mass effect. Radiologically, all GCMs showed mixed T1 and T2 signals; five of them exhibited minimal enhancement after contrast administration. Gross total resection was achieved in all patients without surgical mortality. Postoperatively, three patients developed new surgical complications, including left limbs weakness and left side paralysis. The mean follow-up period after diagnosis was 69.3 months (range, 16-149 months); five patients (55.6%) had achieved full recovery and the remaining four cases (44.4%) were improved to some extent.