Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Oxidative Lipoprotein Markers Predict Poor Functional Outcome in Patients with Minor Stroke or Transient Ischemic Attack
First author：Wang Anxin,Zhang Xinmiao
Corresponding author：Wang Yongjun
essential_information
- Person in charge：Wang Anxin,Zhang Xinmiao
- Data Sources： CHANCE
- Number of papers：OTHERS20190792
- Published time：2019-03-15
2019-03-15
Published articles
Journal：Eur J Neurol
Publication type: Original Article
IF(IF): 6.089
PMID: 30793440 Link To Pubmed Full text Download
Background And Purpose
Method
All patients with minor stroke or TIA were recruited from the Clopidogrel in High-Risk Patients With Acute Non-Disabling Cerebrovascular Events (CHANCE) trial. The poor functional outcome included modified Rankin Scale (mRS) score 2-6 and 3-6 at 90-day and 12-month follow-up. Multivariate logistic regression was used to investigate the associations of oxLDL, oxLDL:HDL and oxLDL:LDL with poor functional outcome.
Conclusion
Higher levels of oxidative lipoprotein markers are independent predictors of poor functional outcome in patients with minor stroke or TIA at 90 days and 12 months.
Main results
Among 3019 patients included in this study, the median (interquartile range) oxLDL, oxLDL:HDL and oxLDL:LDL were 13.96 (6.65-28.81), 4.52 (2.08-9.32) and 11.73 (5.27-24.85) ?g/dL, respectively. After adjusted for confounding factors, patients in the highest oxLDL quartile had a higher proportion of mRS score 2-6 at 90 days [hazard ratio (HR), 1.78; 95% confidence interval (CI), 1.26-2.52] and 12 months (HR, 1.42; 95% CI, 1.01-1.99), and mRS score 3-6 at 90 days (HR, 1.98; 95% CI, 1.29-3.04) and 12 months (HR, 1.77; 95% CI, 1.09-2.89) when compared with the lowest oxLDL quartile (P < 0.05). Similar results were found for oxLDL:HDL and oxLDL:LDL.