Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Population Pharmacokinetic/Pharmacodynamic Model-Guided Dosing Optimization of a Novel Sedative HR7056 in Chinese Healthy Subjects (vol 9, 1316, 2018)
First author：Zhou Ying
Corresponding author：Zhou Ying, Jiang Ji,Chen Xia
essential_information
2019-03-19
Published articles
Journal：Frontiers in Pharmacology
Publication type: Correction
IF(IF): 5.81
PMID: 30941039 Link To Pubmed Full text Download
Background And Purpose
Method
We report on modeling of the data and simulations of dosage regimens for future study. Up to 63 subjects were evaluated, using Bispectral Index (BIS) and Modified Observer’s Assessment of Alertness/Sedation (MOAA/S) as pharmacodynamics endpoints. A three-compartment model best described HR7056 pharmacokinetics. Total clearance was 1.49 L min−1, central volume was 2.1 L, inter-compartmental clearances were 0.96 and 0.27 L min−1, respectively. The population mean pharmacodynamic parameters were as follows: BIS, E0: 95.3; IC50: 503 ng mL−1; γ: 1.5; ke0: 0.0855 min−1; Imax: 47.9 and MOAA/S, IC50: 436 ng mL−1; γ: 1.5; ke0: 0.05 min−1; Imax: 27.9.
Conclusion
The model simulation will enable maintenance doses to be given more accurately for future study.