Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Tremor-Dominant in Parkinson Disease: The Relevance to Iron Metabolism and Inflammation
First author：Lian Tang-Hong
Corresponding author：Zhang Wei
essential_information
- Person in charge：Lian Tang-Hong
- Data Sources： OTHERS
- Number of papers：OTHERS20190812
- Published time：2019-03-27
2019-03-27
Published articles
Journal：Front Neurosci
Publication type: Original Research
IF(IF): 3.648
PMID: 30971879 Link To Pubmed Full text Download
Background And Purpose
Method
A total of 135 PD patients were divided into a tremor-dominant (PD-TD) group (N = 74) and a postural instability and gait difficulty-dominant (PD-PIGD) group (N = 39) based on the ratio of mean tremor score to the mean bradykinesia/rigid score of the Unified Parkinson's Disease Rating Scale (UPDRS) III. Age and sex-matched healthy controls were recruited (N = 35). Demographic variables were evaluated; iron and its metabolism-related proteins and the inflammatory mediators in both CSF and serum were measured in these groups. The relevance of iron metabolism, inflammation and PD-TD were analyzed.
Conclusion
The interplay between disturbed iron metabolism and relevant inflammation might modulate clinical phenotypes of PD.
Main results
(1) The PD-TD group had significantly decreased L-ferritin, increased iron levels in CSF and increased ferritin levels in the serum compared with the PD-PIGD and control groups (P < 0.05). (2) The PD-TD group had significantly enhanced IL-6 levels in both CSF and serum compared with the PD-PIGD and control groups (P < 0.05). (3) In CSF, the IL-6 level was increased as the iron level was elevated in the PD-TD group (r = 0.308, P = 0.022). In serum, the IL-6 level was increased as the ferritin level was elevated in the PD-TD group (r = 0.410, P = 0.004).