Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Peripheral blood test provides a practical method for glioma evaluation and prognosis prediction
First author：Wang Zhi-Liang
Corresponding author：Wang Zheng,Jiang Tao
essential_information
- Person in charge：Wang Zhi-Liang
- Data Sources： OTHERS
- Number of papers：OTHERS20190817
- Published time：2019-03-26
2019-03-26
Published articles
Journal：CNS Neurosci Ther
Publication type: Original Article
IF(IF): 5.243
PMID: 30912613 Link To Pubmed Full text Download
Background And Purpose
Method
We included 260 WHO grades II-IV patients who had preoperative peripheral blood test result from Sanbo hospital as training set. The 66 patients from Tiantan hospital was obtained for validation. RNA sequencing data from CGGA and TCGA datasets were used to evaluate the features of neutrophil subtype and lymphocyte subtype in glioma.
Conclusion
Our data demonstrated that NLR was an important prognostic factor in glioma. We classified that the immune subtype of glioma may contribute to a better understanding of disease pathogenesis and lead to the identification of new therapeutic targets for glioma patients.
Main results
We revealed that the count of preoperative lymphocytes, eosinophils and neutrophils were associated with glioma grades. Neutrophil-to-lymphocyte ratio (NLR) <3.2 was associated with better prognosis, whereas increased NLR was strongly corresponding with a poor prognosis. Lymphocyte type glioma patients demonstrated a positive correlation with isocitrate dehydrogenase (IDH) mutation and lower grade. IDH mutant glioma contained a higher proportion of tumor-infiltrating lymphocytes than IDH wild-type glioma. The immune subtype (neutrophil subtype and lymphocyte subtype) was an independent prognostic factor in glioma.