Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
An Investigation on the Clinical Features and Neurochemical Changes in Parkinson's Disease With Depression
First author：Lian Teng-Hong
Corresponding author：Zhang Wei
essential_information
- Person in charge：Lian Teng-Hong
- Data Sources： OTHERS
- Number of papers：OTHERS20190821
- Published time：2019-01-18
2019-01-18
Published articles
Journal：Frontiers in Psychiatry
Publication type: Original Research
IF(IF): 4.157
PMID: 30713507 Link To Pubmed Full text Download
Background And Purpose
Method
A total of 478 PD patients were divided into PD-D and PD patients without depression (PD-ND) groups according to the 24-item Hamilton Depression Rating Scale (HAMD) score. Demographic variables, motor and non-motor symptoms and activities of daily living were evaluated. The independent influencing factors of PD-D were investigated via binary logistic regression analysis. The levels of neurotransmitters in cerebrospinal fluid (CSF) were measured and their correlations with HAMD score were analyzed.
Conclusion
PD patients have a high proportion of depression, mainly of mild and moderate levels. The profile of depression in PD population is subtly different from that of the general population. Motor symptoms, PIGD type, anxiety and fatigue are the significant influencing factors of PD-D. Compared to 5-HT, DA may play a more important role in PD-D.
Main results
The proportion of PD-D was 59.0%, of which 76.95, 20.92, and 2.13% had mild, moderate, and severe depression, respectively. Anxiety/somatization was the most prevalent sub-factor of HAMD in PD-D. The scores of UPDRS III, postural instability/gait difficulty (PIGD) type and the scores of 14-item Hamilton Anxiety Scale (HAMA) and 14-item Chalder Fatigue Scale (FS) were independently associated with PD-D. The levels of dopamine (DA) and 5-hydroxytryptamine (5-HT) were all significantly reduced in PD-D group compared with those in PD-ND group. HAMD scores were negatively correlated with the DA levels in CSF.