Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
The Role of Disturbed Small-world Networks in Patients with White Matter Lesions and Cognitive Impairment Revealed by Resting State Function Magnetic Resonance Images (rs-fMRI)
First author：Wang Jinfang
Corresponding author：Zhang Yumei
essential_information
- Person in charge：Wang Jinfang
- Data Sources： OTHERS
- Number of papers：OTHERS20190850
- Published time：2019-01-11
2019-01-11
Published articles
Journal：Medical Science Monitor
Publication type: Research Article
IF(IF): 2.649
PMID: 30634184 Link To Pubmed Full text Download
Background And Purpose
Method
All study participants were prescreened using MRI and neuropsychological tests. Patients with WMLs were further divided into 2 groups according to the result of Montreal Cognitive Assessment (MoCA), i.e., WMLs with non-dementia vascular cognitive impairment (WMLs-VCIND) and WMLs with vascular dementia (WMLs-VaD). Resting-state functional MRI data were collected and applied with graph theoretical analysis to compare small-world properties between the 3 groups
Conclusion
These findings suggest potential constructive reorganization of brain networks secondary to WMLs, and provides novel insights into the role of small-world properties in cognitive dysfunction in WMLs.
Main results
We found that the overall functional connectivity strength was lowest in the WMLs-VaD patients but highest in the normal control study participants. Patients in both the WMLs-VCIND and the WMLs-VaD groups had decreased small-world properties compared with the group of normal control study participants. Moreover, the small-world properties significantly correlated with MoCA scores.