Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Hepatitis B virus infected patients show increased risk of cerebral aneurysm rupture: A retrospective analysis
First author：Yang Ziwen
Corresponding author：Zhao Jizong
essential_information
- Person in charge：Yang Ziwen
- Data Sources： OTHERS
- Number of papers：OTHERS20190870
- Published time：2019-05-01
2019-05-01
Published articles
Journal：Journal of Clinical Neuroscience
Publication type: Clinical Commentary
IF(IF): 1.961
PMID: 30850179 Link To Pubmed Full text Download
Background And Purpose
Method
We retrospectively studied patient details and serological markers of HBV infection among 229 patients presenting with CA on admission to the Neurosurgery Department at Beijing Tiantan Hospital between March 2016 and February 2017. Clinical data, radiologic findings and clinical features of HBV infection were analyzed by SPSS. The results showed a significant association between HBsAg positive (p = 0.014), anti-HBc positive (p = 0.045) and CA rupture. Univariate analysis revealed patients that were HBsAg positive (OR: 4.828; 95% CI: 1.363-17.099; p = 0.015) and anti-HBc positive (OR: 1.804; 95% CI: 1.010-3.223; p = 0.046) were associated with CA rupture. Compared with other confounding risk factors for rupture in the statistical analysis, HBsAg positive status (OR: 4.085; 95% CI: 1.011-16.513; p = 0.048) remained positively associated with CA rupture.
Conclusion
Observation showed that HBsAg positivity was associated with CA rupture.
Main results
We retrospectively studied patient details and serological markers of HBV infection among 229 patients presenting with CA on admission to the Neurosurgery Department at Beijing Tiantan Hospital between March 2016 and February 2017. Clinical data, radiologic findings and clinical features of HBV infection were analyzed by SPSS. The results showed a significant association between HBsAg positive (p = 0.014), anti-HBc positive (p = 0.045) and CA rupture. Univariate analysis revealed patients that were HBsAg positive (OR: 4.828; 95% CI: 1.363-17.099; p = 0.015) and anti-HBc positive (OR: 1.804; 95% CI: 1.010-3.223; p = 0.046) were associated with CA rupture. Compared with other confounding risk factors for rupture in the statistical analysis, HBsAg positive status (OR: 4.085; 95% CI: 1.011-16.513; p = 0.048) remained positively associated with CA rupture.