国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
White matter connection's damage, not cortical activation, leading to language dysfunction of mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes
第一作者：Ye Na
通讯作者：Zhang Yu-Mei
2019-03-05
已发表文章
发表杂志：Chinese Medical Journal
发表类型: Clinical Observation
影响因子(IF): 2.628
PMID: 30707182 Pubmed原文链接 全文下载
主要研究背景及目的
方法
Mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes (MELAS) is a metabolic disorder characterized by hyperlactic acidemia and stroke-like symptoms.[1] The clinical symptoms of MELAS are complex and diverse, with an incidence of 39.47% of aphasia.[2] MELAS is often considered to be gray matter damage, little studies investigated its white matter changes. However, many studies have shown that for stroke patients, white matter played an important role in language dysfunction, especially in conductive aphasia.[3] Therefore, language function disorder is an ideal target for exploring white matter's role in MELAS. This study aimed to discover which damage caused the abnormal symptoms in a particular case. First, we measured grey and white matter sizes of the MELAS patient and controls. Second, we investigated the cortical activation's decrease (based on a Blood oxygenation level dependent functional magnetic resonance imaging [BOLD-fMRI], white matter connections’ damage (based on diffusion tensor imaging [DTI]) and proposed a hypothesis about which of them may be the most likely cause by comparing the two together. This was first done worldwide.
结论
Mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes (MELAS) is a metabolic disorder characterized by hyperlactic acidemia and stroke-like symptoms.[1] The clinical symptoms of MELAS are complex and diverse, with an incidence of 39.47% of aphasia.[2] MELAS is often considered to be gray matter damage, little studies investigated its white matter changes. However, many studies have shown that for stroke patients, white matter played an important role in language dysfunction, especially in conductive aphasia.[3] Therefore, language function disorder is an ideal target for exploring white matter's role in MELAS. This study aimed to discover which damage caused the abnormal symptoms in a particular case. First, we measured grey and white matter sizes of the MELAS patient and controls. Second, we investigated the cortical activation's decrease (based on a Blood oxygenation level dependent functional magnetic resonance imaging [BOLD-fMRI], white matter connections’ damage (based on diffusion tensor imaging [DTI]) and proposed a hypothesis about which of them may be the most likely cause by comparing the two together. This was first done worldwide.