国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Predictive Value of the ABCD3-I for Short- and Long-Term Stroke after TIA with or without sICAS

第一作者：Xuewei Xie,Jingjing

通讯作者：Yongjun Wang

Transient ischemic attack Intracranial artery stenosis Risk prediction ABCD3-I Stroke incidence

基本信息

2021-11-06

已发表文章

发表杂志：Journal of Atherosclerosis and Thrombosis

发表类型: Article

影响因子(IF): 4.394

PMID: 34744099 Pubmed原文链接 全文下载

主要研究背景及目的

ABCD3-I 是目前TIA人群最佳的风险预测模型，其中影像标志物为出现DWI梗死病灶及颈动脉狭窄。然而，颅内动脉狭窄亚洲人群特异性的发病病因，且伴有颅内动脉狭窄的患者卒中复发风险显著增加。目前尚不明确在颅内动脉狭窄和非颅内动脉狭窄患者ABCD3-I的风险预测效能是否一致。

方法

We recruited TIA patients from the Third China National Stroke Registry study. Outcome parameters were stroke events during the 14-day, 3-month, 6-month, and 12-month points. The area under the curve (AUC) was calculated as a measure of predictive ability. A multivariable-adjusted Cox proportional hazards model was used to assess the hazard ratio of risk factors for stroke.

结论

ABCD3-I score performed well in predicting short-term risk of a stroke after an index TIA in patients with or without sICAS. However, the predictive power decayed with the prolonged period, and the decayed extent was more pronounced among those with sICAS. The assessment of sICAS is a non-ignorable item when using the ABCD3-I score for long-term stroke risk prediction in patients with TIA.

主要结果

Among 986 patients, 3.9%, 5.1%, 6.5 %, and 8.2% of participants experienced a stroke event during the 14-day, 3-month, 6-month, and 12-month points post TIA, respectively. The AUCs of ABCD3-I score for the prediction of stroke were 0.786, 0.732, 0.715, and 0.699 at the 14-day, 3-month, 6-month, and 12-month points, respectively. The AUCs were 0.774, 0.690, 0.617, and 0.611 in patients with sICAS, 0.789, 0.748, and 0.758 and 0.734 in those without sICAS. P values of the interaction between ABCD3-I categories and sICAS were 0.0618 for 14-day, 0.0098 for 3-month, 0.0318 for 6-month, and 0.0294 for 12-month.