国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Relationship between glycosylated hemoglobin and short-term mortality of spontaneous intracerebral hemorrhage

第一作者：陆平

通讯作者：赵性泉

HbA1c glucose diabetes intracerebral hemorrhage mortality

基本信息

负责人：陆平
数据来源： CSCA
论文编号：CSCA20191014
发表时间：2021-04-16

2021-04-16

已发表文章

发表杂志：Frontiers in Neurology

发表类型: Original Research

影响因子(IF): 4.003

PMID: 33935947 Pubmed原文链接全文下载

主要研究背景及目的

脑出血是指原发性非外伤性脑实质内出血，占急性脑血管病的20%-30%，在急性脑血管病中病死率最高，且预后不佳。HBA1C可以提示近期血糖水平，受短时干扰较少，相较血糖更加稳定。目前国际上针对大规模亚洲人群HBA1C水平与脑出血治疗结局研究相对缺乏。我们使用CSCA研究中的HBA1C和临床结果数据，旨在研究脑出血患者入院时不同HBA1C 水平对于脑出血死亡率（主要结局）及出院状况（次要结局）的影响的差异。目的：用以指导脑出血人群HBA1C水平日常检测及控制，改善人群预后。

方法

It was a large-scale, multicenter, cross-sectional study. From August 1, 2015, to July 31, 2019, a total of 41910 SICH patients were included in the study from the Chinese Stroke Center Alliance (CSCA) program. Finally, we comprehensively analyzed the data from 21116 patients with SICH. HbA1c was categorized into 4 groups by quartile. Univariate and multivariate logistic regression analyses were used to assess the association between HbA1c levels and short-term mortality in SICH patients.

结论

Therefore, we concluded that low or extremely low HbA1c levels (≤ 5.10%) after stroke was associated with higher short-term mortality in SICH patients, with or without DM.

主要结果

The average age of the 21116 patients was 62.8 ± 13.2 years old, 13052 (61.8%) of them were male and 507（2.4%）of them were died. Compared to the higher three quartiles of HbA1c, the lowest quartile (≤ 5.10%) had higher short-term mortality. In subgroup analysis with or without diabetes mellitus (DM) patients, the mortality of Q3 group 5.60% – 6.10% was significantly lower than that of Q1 group ≤ 5.10%. After adjustment for potential influencing factors, the ROC curve of HbA1c can better predict the short-term mortality of patients with SICH（AUC＝0.6286 P < 0.001).