国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
2021-10-17
已发表文章
发表杂志：International Journal of Stroke
发表类型: Original Contributions
影响因子(IF): 5.266
PMID: 34657527 Pubmed原文链接 全文下载
主要研究背景及目的
研究背景：后循环缺血性卒中的预后较差，但是目前尚不清楚国人非心源性后循环缺血性卒中责任动脉的分布情况，以及后循环颅内、颅外病变所致缺血性卒中的比例。而且椎动脉和非椎动脉病变所致非心源性缺血性卒中的临床、影像学表现和预后是否存在差异，目前研究报道较少。 研究目的：研究国人非心源性后循环缺血性卒中责任动脉的分布情况，以及后循环颅内、颅外病变所致缺血性卒中的比例。探索椎动脉和非椎动脉病变所致非心源性缺血性卒中的临床、影像学表现和预后是否存在差异。
方法
We prospectively enrolled 228 patients from 22 Chinese centers with noncardiogenic posterior circulation stroke due to vertebral artery disease. Vertebral artery disease was classified by the involved segments of the responsible vertebral artery, and basilar artery (BA) involvement or not. Risk factors, clinical-radiologic patterns, and outcomes were compared across different types of vertebral artery disease.
结论
The risk factors for ICVA/ICVA+ECVA were different from those of ECVA, and the MSVA/SSVA+BA group had more serious clinical-radiologic patterns and worse outcomes.
主要结果
The intracranial vertebral artery (ICVA) was more frequently involved than was the extracranial vertebral artery (ECVA). The ICVA/ICVA+ECVA group more often presented with hypertension and higher systolic blood pressure than did the ECVA group. Compared with the single-segment-of-vertebral-artery group (SSVA), the group with multiple-segments-of-vertebral-artery (MSVA) involvement or SSVA with BA involvement had more serious clinicalradiologic patterns and worse outcomes. Multivariable Cox regression identified MSVA/SSVA+BA involvement as an independent predictor of recurrent ischemic cerebrovascular events.