国家神经系统疾病临床医学研究中心数据管理与共享系统

发表杂志：Journal of the American Heart Association

发表类型: Original Contributions

影响因子(IF): 6.106

PMID: 35243903 Pubmed原文链接 全文下载

As key enzymes of cell energy metabolism, creatine kinase (CK) is expressed widely in tissues, especially in muscle and brain tissues. CK has tissue distribution specificity and there are three isozymes (CK-MM, CK-MB and CK-BB) in cytoplasm. CK-MM mainly exists in skeletal muscle, CK-MB in cardiac muscle and CK-BB primarily in brain. CK and CK isozymes were found to be elevated in cerebrovascular events, muscle disease, myocardial ischemia and can be used as markers of tissue damage. Many studies found that serum CK was raised in stroke patients, although tissue sources and potential mechanism were not entirely clear. However, studies were very limited about the relation between serum CK and clinical outcomes of stroke. In this study, we aimed to investigate the influences of elevated serum CK on recurrence and functional outcomes of acute ischemic stroke (AIS) or transient ischemic attack (TIA).

Baseline serum CK levels were measured. Normal upper limit of men and women were set differently. The associations between CK and clinical outcomes (stroke recurrence, death and disability) were analyzed with logistic regression model. The Kaplan-Meier product-limit method was used to estimate the incidence rates of recurrent stroke, ischemic stroke, combined vascular events and death during the follow-up period. Cox proportional-hazards model or multivariate regression model was used to test the interaction between CK and sex or age