国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Leukocyte subtypes and adverse clinical outcomes in patients with acute ischemic cerebrovascular events
通讯作者：Yongjun Wang
基本信息
- 负责人：Anxin Wang,Kehua Quan
- 数据来源： CNSR-Ⅲ
- 论文编号：CNSR-Ⅲ20200187
- 发表时间：2021-05-17
2021-05-17
已发表文章
发表杂志：Annals of Translational Medicine
发表类型: Original Article
影响因子(IF): 3.932
PMID: 10.21037/atm-20-7931 Pubmed原文链接 全文下载
主要研究背景及目的
The aim of this study was to evaluate whether the effects on long-term clinical outcomes were differed by leukocyte subtypes in patients with acute ischemic cerebrovascular events including both ischemic stroke and TIA.
方法
We derived data from the Third China National Stroke Registry (CNSR-III). The counts and percentages of each leukocyte subtype were collected within the first 24 hours after admission. Enrolled patients were classified into four groups by the quartiles of each leukocyte subtype count or percentage. Hazard ratios (HRs) or odds ratios (ORs) and their 95% confidence intervals (CIs) of adverse clinical outcomes were calculated, with the lowest quartile group as the reference category. We used C statistics, integrated discrimination improvement (IDI), and the net reclassification index (NRI) to evaluate each leukocyte subtype’s incremental predictive value beyond conventional risk factors.
结论
Leukocyte subtypes had different relationships with adverse clinical outcomes at 3-month and 1-year follow-up in patients with acute ischemic cerebrovascular events and could slightly increase the predictive value compared with the conventional model.
主要结果
A total of 14,174 patients were enrolled. Higher counts of leukocytes, neutrophils, and monocytes were associated with elevated risks of adverse clinical outcomes. In contrast, higher counts of lymphocytes and eosinophils were related to reduced risks of adverse clinical outcomes. Meanwhile, basophil counts seemed to not correlate with adverse clinical outcomes. Furthermore, there were also significant associations between the percentages of leukocyte subtypes and adverse clinical outcomes.