国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
2022-08-18
已发表文章
主要研究背景及目的
研究背景：目前关于国人后循环颅内动脉病变所致缺血性卒中责任动脉和病因分型的分布情况的研究较少。而且目前尚不清楚后循环不同部位颅内动脉病变所致缺血性卒中的临床、影像学表现和预后是否存在显著差异。 研究目的：研究国人后循环颅内动脉病变所致缺血性卒中责任动脉、病因分型的分布情况，以及后循环不同部位颅内动脉病变所致缺血性卒中的临床、影像学表现和预后是否存在显著差异。
方法
We prospectively enrolled 690 patients from 22 Chinese centers with noncardiogenic PCS due to intracranial artery disease. Intracranial artery disease was classified as intracranial vertebral artery disease (IVAD) and intracranial nonvertebral artery disease (INVAD).Clinical-radiologic patterns and outcomeswere compared between IVAD and INVAD.
结论
PCS due to INVAD was more common in the Chinese population. However, PCS due to IVAD had more serious clinical-radiologic patterns and worse outcomes.
主要结果
INVAD was more frequent than IVAD. Compared to the INVAD group, the IVAD group more frequently had hypertension, coronary heart disease, multiple infarcts, border zone infarcts, territorial infarcts, small cortical infarcts, multilevel infarcts, multisector infarcts, and more often had severe stenosis of the responsible artery, more often presented with decreased alertness, gaze palsy, bilateral limb weakness, ataxia, dysphagia, diplopia, vertigo, and headache. In addition, the IVAD group had a higher National Institutes ofHealth stroke scale score and modified Rankin Scale score at discharge and more deaths and recurrent ischemic cerebrovascular disease within 1 year of onset.Multivariable Cox regression identified IVADas an independent predictor of recurrent ischemic cerebrovascular disease.