国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Discordantly high Apo B with LDL-C or non-HDL-C in relation to presence and burden of cerebral atherosclerotic plaques
第一作者：Chao Li; Yanli Zhang
通讯作者：Rui Chen , Yu Tian
基本信息
- 负责人：Chao Li; Yanli Zhang
- 数据来源： PRECISE
- 论文编号：PRECISE20220043
- 发表时间：2023-06-03
2023-06-03
已发表文章
发表杂志：Journal of Clinical Lipidology
发表类型: Original Contributions
影响因子(IF): 4.4
PMID: 37316392 Pubmed原文链接 全文下载
主要研究背景及目的
Discordant levels of apolipoprotein B (Apo B) relative to low-density lipoprotein cholesterol (LDL-C) or Non-high lipoprotein cholesterol (Non-HDL-C) may be associated with atherosclerotic cerebrovascular disease. The present study evaluated whether discordance between Apo B and LDL-C or Non-HDL-C levels was associated with atherosclerotic cerebrovascular disease measured by intracranial atherosclerotic and extracranial atherosclerotic plaque or burden.
方法
Methods:This cross-sectional study was based on the baseline survey from the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study, a population-based prospective cohort study. Participants with complete baseline data but without taking lipid-lowering medication were included in this analysis. Discordant Apo B with LDL-C or Non-HDL-C were defined by residuals and cut-off values (LDL-C: 3.4 mmol/L, Non-HDL-C: 4.1 mmol/L). We used binary and ordinal logistic regression models to explore associations between discordant Apo B with LDL-C or Non-HDL-C and the presence and burden of intra-/extra-cranial atherosclerotic plaques.
结论
Methods:This cross-sectional study was based on the baseline survey from the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study, a population-based prospective cohort study. Participants with complete baseline data but without taking lipid-lowering medication were included in this analysis. Discordant Apo B with LDL-C or Non-HDL-C were defined by residuals and cut-off values (LDL-C: 3.4 mmol/L, Non-HDL-C: 4.1 mmol/L). We used binary and ordinal logistic regression models to explore associations between discordant Apo B with LDL-C or Non-HDL-C and the presence and burden of intra-/extra-cranial atherosclerotic plaques.
主要结果
Methods:This cross-sectional study was based on the baseline survey from the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study, a population-based prospective cohort study. Participants with complete baseline data but without taking lipid-lowering medication were included in this analysis. Discordant Apo B with LDL-C or Non-HDL-C were defined by residuals and cut-off values (LDL-C: 3.4 mmol/L, Non-HDL-C: 4.1 mmol/L). We used binary and ordinal logistic regression models to explore associations between discordant Apo B with LDL-C or Non-HDL-C and the presence and burden of intra-/extra-cranial atherosclerotic plaques.burden of intra-/extra-cranial atherosclerotic plaques.