国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Reduced white matter microstructural integrity in prediabetes and diabetes: A population-based study

第一作者：jing jing,Yijun Zhou,Yuesong Pan,Xueli Cai

通讯作者：Tao Liu,Tiemin Wei,Yongjun Wang

white matter microstructural prediabetes diabetes

基本信息

2022-07-07

已发表文章

发表杂志：ebiomedicine

发表类型: Original Contributions

影响因子(IF): 11.205

PMID: 35810560 Pubmed原文链接 全文下载

主要研究背景及目的

Background White matter (WM) microstructural abnormalities have been observed in diabetes. However, evidence of prediabetes is currently lacking. This study aims to investigate the WM integrity in prediabetes and diabetes. We also assess the association of WM abnormalities with glucose metabolism status and continuous glucose measures.

方法

Methods The WM integrity was analyzed using cross-sectional baseline data from a population-based PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study. The cohort, including a total of 2218 cases with the mean age of 61.3 § 6.6 years and 54.1% female, consisted of 1205 prediabetes which are categorized into two subgroups (a group of 254 prediabetes with combined impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and the other group of 951 prediabetes without combined IFG/IGT), 504 diabetes, and 509 normal control subjects. Alterations of WM integrity were determined by diffusion tensor imaging along with tract-based spatial statistics analysis to compare diffusion metrics on WM skeletons between groups. The mixed-effects multivariate linear regression models were used to assess the association between WM microstructural alterations and glucose status.

结论

Interpretation Our findings suggest that WM microstructural abnormalities are already present at the prediabetes with combined IFG/IGT stage. Preventative strategies should begin early to maintain normal glucose metabolism and avert further destruction of WM integrity.

主要结果

Findings Microstructural abnormalities distributed in local WM tracts in prediabetes with combined IFG/IGT andspread widely in diabetes. These WM abnormalities are associated with higher glucose measures.