国家神经系统疾病临床医学研究中心数据管理与共享系统

发表杂志：SVN

发表类型: Original Contributions

影响因子(IF): 5.9

PMID: 37989483 Pubmed原文链接 全文下载

Cerebral small vessel disease (CSVD) encompasses a group of pathological processes that affect small penetrating vessels (arterioles, capillaries and venules) of the brain. It is a serious threat to public health and poses substantial burden on patients, their proxies, societies and health-care systems. The risk factors of CSVD are unclear. Previous studies suggested some individual lifestyle risk factors were associated with CSVD, but related results were not consistent. In 2022 the American Heart Association (AHA) proposed an overall score - Life’s Essential 8 (LE8) -which is an enhanced approach to assessing cardiovascular health and updated from Life’s Simple 7 (LS7). LE8 which assessed cardiovascular health status was an effective means to monitor public and individual health and a strong indicator of the extraordinary potential of primordial prevention strategies to improve and extend countless lives. To our knowledge, LE8 has been used in the field of cardiovascular health, and previous studies have examined the associations between LS7 and stroke or dementia which is closely related to CSVD. But the association between LE8 and CSVD or its magnetic resonance imaging (MRI) markers was unclear. In this study, we investigated associations of LE8 with presence of CSVD, total CSVD score and MRI markers in community-dwelling adults based on the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study. In this study, we investigated associations of LE8 with presence of CSVD, total CSVD score and MRI markers in community-dwelling adults based on the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study.

LE8 was analyzed as the total score, medical score and behavioral score, and they were categorized as low (0-60), moderate (60-80), or high (80-100) group. The burden of CSVD and its MRI markers (white matter hyperintensities, lacunes, cerebral microbleeds, enlarged perivascular spaces) were evaluated according to two criteria -total CSVD score and modified total CSVD score. The associations of LE8 scores with CSVD and MRI markers were analyzed by binary logistic regression or ordinal logistic regression model.