国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

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Moderate elevation of serum uric acid improves short-term functional outcome in ischemic stroke patients with type 2 diabetes mellitus

第一作者：Yalun Dai,Yingyu Jiang

通讯作者：Yongjun Wang

serum uric acid ischemic stroke diabetes mellitus functional outcome prognosis

基本信息

2023-07-19

已发表文章

发表杂志：BMC Geriatrics

发表类型: Original Articles

影响因子(IF): 4.1

PMID: 37468868 Pubmed原文链接 全文下载

主要研究背景及目的

Serum uric acid (SUA), as the end product of purine catabolism diffused in the blood, is positively associated with the risk of type 2 diabetes mellitus (T2DM). However, the association of the fluctuation of SUA and stroke functional outcomes in ischemic stroke (IS) patients with T2DM is still unclear. This study aimed to evaluate the association between the fluctuation of SUA and short-term functional outcome in IS patients with T2DM.

方法

All T2DM patients diagnosed with IS in the China National Stroke Registry III were included. ∆SUA, which was defined as the difference between the SUA levels at baseline and 3 months at discharge, was classified into two groups, i.e., elevated ∆SUA (∆SUA>0) and reduced ∆SUA (∆SUA≤0). The primary outcome was poor functional outcomes (Modified Rankin Scale, 3–6) at 3 months after IS.

结论

This study showed that elevated ∆SUA in the range of 0–100 μmol/L at 3 months after IS was relevant to a reduced risk of poor functional outcomes in T2DM population, whereas the association of elevated ∆SUA beyond such a range with functional outcomes was not statistically significant.

主要结果

Among the 1255 participants (mean age: 61.6±9.8 years), 64.9% were men. Patients with elevated ∆SUA had a lower incidence of poor functional outcomes at 3 months. Compared with reduced ∆SUA, elevated ∆SUA at 0–50 μmol/L (odds ratio [OR]=0.46, 95% confidence interval [CI]=0.28–0.78, p=0.004) and 50–100 μmol/L (OR=0.40, 95% CI=0.21–0.77, p=0.006) was significantly correlated with a reduced risk of poor functional outcomes at 3 months.