国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Urinary ketone bodies and stroke recurrence in patient with acute ischemic stroke or TIA
第一作者：Liye Dai
通讯作者：Yongjun Wang
2023-09-29
已发表文章
发表杂志：JOURNAL OF CLINICAL NEUROSCIENCE
发表类型: Original Contributions
影响因子(IF): 2
PMID: 37778303 Pubmed原文链接 全文下载
主要研究背景及目的
Urine ketone bodies may appear in different states in the acute stage of stroke. We aimed to examine the association between urine ketone bodies and recurrent stroke in patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA) in this study.
方法
In Third China National Stroke Registry (CNSR-III), 14,015 patients with AIS or TIA were screened for urine ketone bodies. The outcomes were any stroke, ischemic stroke and combined vascular events within 1 year. The association of urine ketone bodies with recurrent stroke were analyzed by Cox proportional hazards.
结论
Positive ketone bodies in urine was independently associated with recurrent stroke in patients with AIS or TIA.
主要结果
During 1 year of follow-up, 1,335 (9.53%) participants experienced recurrent stroke. After adjustment for conventional confounding factors, patients with urine ketone bodies test positive had a higher risk of recurrent stroke (hazard ratio [HR], 1.43; 95% confidence interval [CI], 1.13-1.82), compared to those were negative. The correlation between positive urine ketone bodies and recurrent stroke were consistent in patient with (HR, 1.45; 95% CI, 1.00-2.12) and without (HR, 1.40; 95% CI, 1.02-1.94) diabetes. No significant interaction between urine ketone bodies and diabetes were observed.