国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Association of Early Longitudinal Changes in Neutrophil to Lymphocyte Ratio with Adverse Clinical Outcomes in Acute Ischemic Stroke Patients after Endovascular Treatment

第一作者：Fengli Che

通讯作者：Xiaokun Geng

acute ischemic stroke; endovascular treatment; neutrophil-lymphocyte ratio; functional outcomes; symptomatic intracerebral hemorrhage; mortality

基本信息

  • 负责人：Fengli Che
  • 数据来源： OTHERS
  • 论文编号：OTHERS20230201
  • 发表时间：2023-12-03

2023-12-03

已发表文章

发表杂志：World Neurosurgery

发表类型: Original Contributions

影响因子(IF): 2

PMID: https://pubmed.ncbi.nlm.nih.gov/38052360/ Pubmed原文链接 全文下载

主要研究背景及目的

We aim to elucidate the contribution of early dynamic changes in the neutrophil-to-lymphocyte ratio (NLR) to poor clinical outcomes in acute ischemic stroke (AIS) patients after endovascular treatment (EVT).

方法

AIS patients who underwent EVT were consecutively recruited from January 2019 to July 2022. Blood cell counts were sampled at admission and at following 24 hours after EVT. Clinical outcome measures included 3-month functional dependence (modified Rankin scale of 3-6), symptomatic intracranial hemorrhage (sICH), and mortality at seven days and 30 days. Multinomial logistic regressions were used to evaluate the association of changes in NLR with unfavorable outcomes.

结论

NLR in AIS patients increased remarkably independent of successful reperfusion. Elevated changes in NLR might predict malignant hemorrhagic transformation, adverse functional outcomes, and short-term mortality.

主要结果

590 patients were included in the final analysis. The multinomial logistic model indicated that the increasing changes in NLR after EVT was an independent factor for poor outcomes; the adjusted odds ratio (aOR) was 1.06 (95% CI 1.03-1.10; P<0.001) at poor 3-month functional outcomes, 1.07 (95% CI 1.04-1.10; P<0.001) at sICH, 1.08 (95% CI 1.05-1.12; P<0.001) at mortality at seven days, and 1.04 (95% CI 1.02-1.07; P=0.001) at mortality at 30 days. Areas under the curve (AUC) of changes in NLR to discriminate adverse outcomes were 0.725, 0.687, 0.664, and 0.659. The optimal cut-off values were 5.77 (56.6 % sensitivity, 81.0% specificity), 6.92 (60.0% sensitivity, 77.0% specificity), 8.64 (51.0% sensitivity, 82.0% specificity), and 8.64 (48.7% sensitivity, 83.0% specificity), respectively.