国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Asymptomatic polyvascular disease and the risks of cardiovascular events and all-cause death

第一作者：Qian Zhang,Anxin Wang

通讯作者：Xingquan Zhao, Shouling Wu,Yong Zhou

Polyvascular disease (PolyVD) Asymptomatic Cardio

基本信息

2017-04-20

已发表文章

发表杂志：Atherosclerosis

发表类型: Original Contributions

影响因子(IF): 5.162

PMID: 28463782 Pubmed原文链接 全文下载

主要研究背景及目的

Atherosclerosis is a diffuse and systemic disease. We aimed to assess prevalence and outcome of extracoronary polyvascular disease (polyVD) in the asymptomatic Chinese community population.

方法

A random sample of 5440 participants aged 40 years or older were enrolled in the Asymptomatic Polyvascular Abnormalities Community Study from 2010 to 2011. Intracranial artery stenosis, extracranial artery stenosis, and lower extremity artery disease were detected by transcranial Doppler and duplex sonography, and by calculating the ankle brachial index. The study endpoints included the first occurrence of stroke, myocardial infarction (MI) and all-cause death.

结论

PolyVD significantly increased the risk of major cardiovascular events and all-cause death in the asymptomatic community population. Performing invasive screening tests for polyVD is useful in the high-risk asymptomatic population.

主要结果

PolyVD (two or three affected vascular territories) was found in 3.0% of the participants, and was significantly higher in men (4.3%). Over a median follow-up of 4.1 years, we identified a total of 247 events (4.7%), including 83 strokes (68 ischemic), 45 MIs and 134 all-cause deaths. After adjusting for age, gender and other potential confounders, we found a significant increase in risk of major cardiovascular events as well as all-cause death in participants with polyVD. In multivariate Cox regression analyses, the adjusted hazard ratios (HR) (95% confidence interval, CI) for the composite of stroke, MI and all-cause death for single and poly-vascular disease (compared with 0 vascular disease) increased from 1.58 (1.19e2.12) to 1.95 (1.26e3.03). Similarly, the adjusted HR (95% CI) for all-cause death for single and polyvascular disease increased from 1.53 (1.03e2.29) to 2.22 (1.27e3.86).