Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Validation of the ABCD2-I score to predict stroke risk after transient ischemic attack
First author：Xia Meng
Corresponding author：Yongjun Wang
essential_information
2011-06-01
Published articles
Journal：Neurological Research
Publication type: Original Contributions
IF(IF): 2.448
PMID: 21669116 Link To Pubmed Full text Download
Background And Purpose
The primary aim of this study was to prospectively validate the predictive value of the ABCD2-I score and to then compare the predictive accuracy of the ABCD2 score and ABCD2-I score for 1-year risk of stroke in admitted patients with transient ischemic attack (TIA) as defined by the World Health Organization (WHO) time-based criteria.
Method
Data were collected from patients with transient ischemic attack within 7 days of symptom onset, and all patients underwent diffusion-weighted imaging (DWI). The predictive values of stratified 1-year rates of recurrent stroke were compared using the age, blood pressure, clinical signs, symptom duration, and ABCD2 score with defined cutoff values (0–3, low-risk, 4–5, medium-risk, 6–7, high-risk) and ABCD2-I score cutoff values (0–3, low-risk, 4–6, medium-risk, 7–10, high-risk). In addition, to evaluate the performance of the two scores, we calculated the area under the curve by receiver-operating characteristic.
Conclusion
The ABCD2-I score is a useful tool for stratifying the 1-year risk of stroke in TIA patients, and it improves the discriminatory power of the ABCD2 score for the prediction of stroke risk.
Main results
Four hundred and ten patients with completed DWI and 12-month follow-up with initial TIA were enrolled in this study. Of these, 111 (27.07%) patients had annual stroke risk. The risk of stroke increased with increasing ABCD2 score and ABCD2-I score. The ABCD2-I score had the higher predictive value with areas under the curve of 0.77 than the ABCD2 score with areas under the curve of 0.59.