国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Association between β-cell function estimated by HOMA-β and prognosis of nondiabetic patients with ischaemic stroke

第一作者：Yuesong Pan,Mengyuan Zhou

通讯作者：Yilong Wang

β-cell dysfunction HOMA-β ischaemic stroke non-dia

基本信息

2018-03-01

已发表文章

发表杂志：Eur J Neurol.

发表类型: Original Contributions

影响因子(IF): 3.988

PMID: 29222957 Pubmed原文链接 全文下载

主要研究背景及目的

Studies showed that β‐cell dysfunction is associated with increased risk of cardiovascular disease and subclinical carotid atherosclerosis. This study aimed to investigate the association between β‐cell function and prognosis of non‐diabetic patients with ischaemic stroke.

方法

Ischaemic stroke patients without diabetes in the Abnormal Glucose Regulation in Patients with Acute Stroke across China registry were included in this analysis. Homeostasis assessment of β‐cell function (HOMA‐β) was performed and classified into four groups according to quartiles. The outcomes included stroke recurrence, poor functional outcome and all‐cause mortality.

结论

Our study shows that lower HOMA‐β level is associated with poor outcomes at 1 year in non‐diabetic patients with ischaemic stroke.

主要结果

In a total of 1244 patients, the average age was 62.3 years; 63.1% patients were male. At 1 year, the first quartile of HOMA‐β (<54.0) was associated with increased stroke recurrence (adjusted hazard ratio 2.04, 95% confidence interval 1.32–3.17, P = 0.001), poor functional outcome (adjusted odds ratio 3.04, 95% confidence interval 1.90–4.88, P < 0.001) and mortality (adjusted hazard ratio 4.12, 95% confidence interval 2.24−7.59, P < 0.001) compared with the fourth quartile of HOMA‐β (≥166.3) after adjustment for insulin resistance and other potential covariates. The second and third quartiles of HOMA‐β were significantly associated with an increased risk of poor functional outcome. Multivariable regression analysis with restricted cubic splines showed an L‐shaped association between HOMA‐β and outcomes at 1 year.