国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Intracranial or extracranial arterial stenosis and the prognosis of transient symptoms with or without infarction
第一作者：Suo, yue
通讯作者：Wang, yongjun
2020-08-13
已发表文章
主要研究背景及目的
According to a national population-based survey in 2010, approximately 23.9 million people in China may have TIA.1 Long-term risk of recurrent cerebrovascular events after TIA varied from 6.2% to 12%.2, 3 Among all the predictors of recurrent cerebrovascular events after TIA, imaging parameters such as intracranial stenosis are critically important.4 The American stroke society initiated an tissue-based definition of TIA, a brief episode of neurological dysfunction caused by focal ischemia in the brain, spinal cord, or retina without evidence of acute cerebral infarction.5 Up to 39% of time-defined TIA patients had DWI-hyperintensities on MRI.6 We aim to investigate the influence of intra-/extracranial artery stenosis on prognosis of transient symptoms with or without infarction.
方法
The study population will be divided into 3 groups according to state of artery stenosis. Baseline characteristics will be compared among groups. We will present the categorical variables as proportions, continuous variables as mean and SD. In the univariate analysis, Kruskal-Wallis test was used for comparisons of skewed continuous variables and ordinal variable. Categorical variables were compared with the r2 statistics or Fisher exact test as appropriate. Cox proportional hazard regression model and logistic regression model will be used to analyze the association of different stenosis status with onset age and TIA prognosis. Stratified analysis by DWI hyperintensity, focal ischemia location(brain supplied by anterior/posterior circulation; spinal cord; retina) and severity of stenosis) will also be performed. A two-sided P value of less than 0.05 will be considered to reach statistical significance. All statistical analyses will be performed by using SAS version 9.4 software (SAS Institute Inc., Cary, NC, USA).
结论
Concurrent ICAS and ECAS is associated with a higher possibility of 1-year recurrent stroke or composite vascular events. Large artery evaluation is necessary to assess patients with transient ischaemic symptoms or DWI-negative AIS. Progress in shortening the time interval between symptom onset and large vessel evaluation is needed.