Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Higher Levels of Lipoprotein Associated Phospholipase A2 is associated with Increased Prevalence of Cognitive Impairment: the APAC Study
First author：Ruixuan Jiang,Shengyun Chen
Corresponding author：Xingquan Zhao,Shouling Wu
essential_information
- Person in charge：Ruixuan Jiang,Shengyun Chen
- Data Sources： APAC
- Number of papers：APAC20190127
- Published time：2016-09-09
2016-09-09
Published articles
Journal：Scientific Reports
Publication type: Original Contributions
IF(IF): 4.379
PMID: 27609335 Link To Pubmed Full text Download
Background And Purpose
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a unique circulating phospholipase with inflammatory and oxidative activities and the limited data regarding the relationship between Lp-PLA2 and cognitive impairment are conflicted.
Method
We conducted a cross-sectional study including 1,374 Chinese adults recruited from 2010 to 2011, aiming to evaluate the relationship between Lp-PLA2 levels and the prevalence of cognitive impairment in a Chinese community-based population. Participants underwent standardized evaluation. Serum Lp-PLA2 mass was measured by ELISA. Cognition status was evaluated via the Mini-Mental Status Exam (MMSE) and cognitive impairment was identified as MMSE <24. Multivariable logistic regression models were used to assess the associations of Lp-PLA2 mass with cognitive impairment.
Conclusion
In conclusion, elevated level of Lp-PLA2 mass was independently associated with the prevalence of cognitive impairment in Chinese adults.
Main results
Lp-PLA2 mass was significantly associated with the prevalence of cognitive impairment after adjusting for other potential confounding factors (compared with the first quartile, adjusted ORs of the second, third, and fourth quartile were 2.058 (95% CI, 0.876–4.835), 2.834 (95% CI, 1.255–6.398), and 4.882 (95% CI, 2.212–10.777), p < 0.0001).