国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

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Soluble CD40L Is a Useful Marker to Predict Future Strokes in Patients With Minor Stroke and Transient Ischemic Attack

第一作者：JIEJIE LI,YILONG WANG

通讯作者：YONGJUN WANG

STROKE PROGNOSIS

基本信息

2015-07-01

已发表文章

发表杂志：STROKE

发表类型: Brief Reports

影响因子(IF): 7.914

PMID: 26012640 Pubmed原文链接 全文下载

主要研究背景及目的

Elevated soluble CD40 ligand (sCD40L) was shown to be related to cardiovascular events, but the role of sCD40L in predicting recurrent stroke remains unclear

方法

Baseline sCD40L levels were measured in 3044 consecutive patients with acute minor stroke and transient ischemic attack, who had previously been enrolled in the Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events (CHANCE) trial. Cox proportional-hazards model was used to assess the association of sCD40L with recurrent stroke.

结论

Elevated sCD40L levels independently predict recurrent stroke in patients with minor stroke and transient ischemic attack.

主要结果

Patients in the top tertile of sCD40L levels had increased risk of recurrent stroke comparing with those in the bottom tertile, after adjusted for conventional confounding factors (hazard ratio, 1.49; 95% confidence interval, 1.11– 2.00; P=0.008). The patients with elevated levels of both sCD40L and high-sensitive C-reactive protein also had increased risk of recurrent stroke (hazard ratio, 1.81; 95% confidence interval, 1.23–2.68; P=0.003).