国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Frequency and risk factors of spontaneous hemorrhagic transformation following ischemic stroke on the initial brain CT or MRI: data from the China National Stroke Registry (CNSR)
基本信息
- 负责人：Guojuan Chen,Anxin Wang
- 数据来源： CNSR-I
- 论文编号：CNSR-I20190147
- 发表时间：2016-06-20
2016-06-20
已发表文章
发表杂志：Neurological Research
发表类型: Original Contributions
影响因子(IF): 2.448
PMID: 27320249 Pubmed原文链接 全文下载
主要研究背景及目的
There are few studies of spontaneous hemorrhagic transformation (HT) after ischemic stroke (IS), and those that are available do not preclude the use of antithrombotic therapy after admission. We aimed to investigate the frequency and risk factors of spontaneous HT in patients who received no therapy between IS onset and the first instance of neurological imaging.
方法
We studied spontaneous HT using the China National Stroke Registry. Spontaneous HT was diagnosed on an initial computed tomography or magnetic resonance imaging scan within 14 days of IS onset. The risk factors associated with spontaneous HT were assessed using univariate analyses and multivariate logistic regression.
结论
Spontaneous HT occurred in 0.92% of the patients with IS in the acute stage. Being female, excess alcohol consumption, atrial fibrillation, and a prolonged period between IS onset and initial imaging were associated with an increased risk of spontaneous HT.
主要结果
A total of 12,415 patients were diagnosed with IS, and among them, 114 (0.92%) had spontaneous HT. Multivariate analysis revealed that being female odds ratio (OR, 2.29; 95% CI, 1.52–3.44, p < 0.0001), excess alcohol consumption (OR, 2.17; 95% CI, 1.20–3.94, p = 0.0109), atrial fibrillation (OR, 2.15; 95% CI, 1.26–3.66, p = 0.0051), and a prolonged period between IS onset and initial imaging (1–7 days: OR, 1.64, 95%CI, 1.11–2.42, p = 0.0131; 7–14 days: OR, 3.12, 95% CI, 1.53–6.40, p = 0.0018) were positively associated with spontaneous HT.