国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Association of ideal cardiovascular health metrics and cognitive functioning: the APAC study

第一作者：Ning Zhang,Yuling Yang

通讯作者：Shouling Wu,Chunxue Wang,Xingquan Zhao

cognitive functioning ideal cardiovascular health

基本信息

2016-06-01

已发表文章

发表杂志：European Journal of Neurology

发表类型: Original Contributions

影响因子(IF): 6.089

PMID: 27251451 Pubmed原文链接 全文下载

主要研究背景及目的

Previous studies have demonstrated that the components of ideal cardiovascular health (CVH) metrics are related to dementia.This study aimed to investigate the overall effects of ideal CVH metrics on cognitive functioning.

方法

Information was collected on the seven ideal CVH metrics (smoking, body mass index, dietary intake, physical activity, blood pressure, total cholesterol and fasting blood glucose) from the Asymptomatic Polyvascular Abnormalities Community study, and cognitive functioning was assessed by the score of the Mini-Mental State Examination (MMSE). Multivariate logistic regression and linear regression models were used to assess the relationships between ideal CVH metrics and cognitive functioning.

结论

A clear inverse association was observed between the number or score of ideal CVH metrics and cognitive impairment in a Chinese population, supporting the importance of ideal CVH metrics in prevention of dementia.

主要结果

A total of 3260 (56.7% men) patients were included in this study.After adjusting for potential confounding factors, the associations between the number or score of ideal CVH metrics and cognitive impairment remained significant [odds ratio (OR) (95% confidence interval) 0.773 (0.664–0.928) and 0.904 (0.831–0.983), respectively]. In addition, there were significant linear relationships between the number or score of CVH metrics and the score of the MMSE (b = 0.211 and 0.134 respectively, P < 0.001).