国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Night-time diastolic blood pressure variability relates to stroke recurrence in patients who had ischaemic stroke with small artery occlusion
第一作者：Tingting Wang
通讯作者：Yilong Wang
基本信息
- 负责人：Tingting Wang
- 数据来源： BOSS
- 论文编号：BOSS20190184
- 发表时间：2021-11-30
2021-11-30
已发表文章
主要研究背景及目的
The association between blood pressure variability (BPV) with stroke recurrence is unclear, but may be influenced by different subtypes of ischemic stroke (IS). Aim of this study was to investigate whether BPV measured as 24h-SD of ambulatory blood pressure was associated with certain subtypes of IS.
方法
The subtypes of IS were classified according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. BPV was defined as SD over 24 hours weighted for the time interval between consecutive recordings and the SD of the daytime and night-time periods. Recurrent stroke was defined as a new stroke including IS or intracerebral hemorrhage. Multivariable Cox proportional risk regression model was used to assess the association between BPV and stroke recurrence in patients with different IS subtypes.
结论
High night-time DBPV was associated with increased risks of stroke recurrence among IS patients with SAO subtype. Results of this study provided implications to the secondary prevention management and future researches of IS patients with SAO subtype. The association between BPV and stroke recurrence in IS patients with LAA subtype and SAO subtype should be investigated in larger, population-based studies.
主要结果
In total of 1390 IS patients from BOSS study were included in present study. Multivariable analysis suggested that 24h systolic BPV (SBPV) and night-time diastolic BPV (DBPV) were significantly associated with stroke recurrence among all IS patients (HR, 2.50, 95%CI, 1.07-5.84; HR, 1.85, 95% CI, 1.07-3.21, respectively). Night-time SBPV and night-time DBPV were significantly associated with stroke recurrence in patients with SAO subtype (HR, 2.77, 95%CI, 1.07-7.15; HR, 3.60, 95%CI, 1.39-9.29, respectively). However, only night-time DBPV remained significant in patients with SAO subtype in the adjusted model (HR, 3.87; 95%CI, 1.40-10.71). Similar results were not found in IS patients with LAA subtype.