国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Comparison of centralized VS individualized evaluation of acute ischemic stroke etiologic subtypes and its interaction with presumed treatment on outcomes
第一作者：Suo, yue
通讯作者：Wang, yongjun
2020-11-05
已发表文章
发表杂志：Stroke and vascular neurology
发表类型: Original Contributions
影响因子(IF): 4.081
PMID: 33154178 Pubmed原文链接 全文下载
主要研究背景及目的
Objectives of this study include:1)Compare the centralized stroke etiologic subtyping and individualized stroke etiologic subtyping reported from sub centers; 2)Analyze the potential reasons of the differences between centralized and individualized subtype distribution; 3)Investigate the influence of correlation between subtype assignment and treatment on stroke outcomes.
方法
We will present the categorical variables as proportions, continuous variables as mean and SD. In the univariate analysis, Kruskal-Wallis test was used for comparisons of skewed continuous variables and ordinal variable. Categorical variables were compared with the 2 statistics or Fisher exact test as appropriate. Cox proportional hazard regression model and logistic regression model will be used to analyze the association of reassigned or unchanged subtype and stroke outcomes. Stratified analysis by hospital level, geological location and annual beds will also be performed. A two-sided P value of less than 0.05 will be considered to reach statistical significance. All statistical analyses will be performed by using SAS version 9.4 software (SAS Institute Inc., Cary, NC, USA).
结论
Substantial inconsistency exists between centralised and non-centralised subtyping in China. Inaccurate aetiological subtyping could lead to inadequate secondary prevention, especially in patients with cardioembolic stroke.