国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Predictive values of baseline matrix metalloproteinase 9 levels in peripheral blood on 3-month outcomes of high-risk patients with minor stroke or transient ischemic attack

第一作者：Min Zhang

通讯作者：Yongjun Wang

Matrix Metalloproteinase 9 minor stroke TIA stroke recurrence bleeding events.

基本信息

  • 负责人：Min Zhang
  • 数据来源： CHANCE
  • 论文编号：CHANCE20190252
  • 发表时间：2022-04-11

2022-04-11

已发表文章

发表杂志：European Journal of Neurology

发表类型: Original Article

影响因子(IF): 6.288

PMID: 35357766 Pubmed原文链接 全文下载

主要研究背景及目的

卒中， 包括缺血性卒中和出血性卒中， 是全球死亡和残疾的主要原因。 炎症在中风的发病机制和进展中的作用也越来越受到重视。 基质金属蛋白酶 9（MMP9） 是基质金属蛋白酶（MMPs） 的成员， 参与细胞外基质在各种生理过程中的分解， 已被证明在神经系统疾病的发生和发展中越来越重要。 因此， 本研究旨在探讨 MMP9 对急性非致残性脑血管事件高危人群不良结局的影响。

方法

We assessed data from patients with acute minor ischemic stroke or TIA who were included in the CHANCE trial. Baseline level of MMP9 in peripheral blood is classified into five quintiles. We assessed the relationship between the baseline MMP9 and outcomes of stroke recurrence, composite vascular events, and poor functional outcomes within 90 days after stroke onset.

结论

For patients with acute minor stroke or TIA, higher baseline MMP9 level was associated with an increased risk of poor functional outcomes, which might be related to stroke recurrence and combined vascular events.

主要结果

Of the 3014 patients included, 295 (9.79%) had recurrent stroke, 289 (9.59%) had recurrent ischemic stroke, 297 (9.85%) had combined vascular events, and 199 (6.64%) had poor functional outcomes within 90 days. We used MMP9 concentrations near hazard ratio (HR) = 1 (Q3) in restricted cubic splines as the reference. The result showed that, compared to patients in the Q3 group, patients in the highest quintile (Q5 group) had an increased risk of poor functional outcomes at 90 days after adjusting the risk factors and confounders (p = 0.030), which may be associated with an increased risk of combined vascular events (p = 0.052). Using Cox regression models or logistic regression models with restricted cubic spline, we also observed that higher MMP9 ratios were associated with an increased risk of stroke recurrence, combined events, and poor functional outcomes at a range of concentrations.