国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Neutrophil to lymphocyte ratio and adverse clinical outcomes in patients with ischemic stroke
第一作者：Kehua Quan
通讯作者：Yongjun Wang
基本信息
- 负责人：Kehua Quan
- 数据来源： CNSR-Ⅲ
- 论文编号：CNSR-Ⅲ20190273
- 发表时间：2021-07-15
2021-07-15
已发表文章
发表杂志：Annals of Translational Medicine
发表类型: Original Contributions
影响因子(IF): 3.932
PMID: 34422959 Pubmed原文链接 全文下载
主要研究背景及目的
主要目的：急性脑梗死患者NLR、PLR、LMR与临床预后的关系 次要目的：根据TOAST病因分型分析急性脑梗死患者NLR、PLR、LMR与临床预后的关系
方法
We derived data from the Third China National Stroke Registry. The NLR is defined as neutrophil count/lymphocyte count. Patients included in the study were classified into four groups by NLR quartiles. Odds ratios (ORs) of adverse clinical outcomes were calculated with the lowest quartile group as the reference category. We plotted receiver operating characteristic (ROC) curves of NLR for adverse clinical outcomes and calculated area under the curve (AUC) values and cutoff values. Under different TOAST classifications, medians of NLR and ORs of adverse clinical outcomes were also calculated. Furthermore, interaction tests between NLR and etiology were performed.
结论
High level of NLR within the first 24 h after admission was associated with increased risks of both short- and long-term adverse clinical outcomes in patients with ischemic stroke, regardless of etiology.
主要结果
A total of 13,018 patients were enrolled. At both 3- and 12-month follow-ups, higher quartile groups were associated with increased risks of death and poor functional outcomes, even after adjustments. For death, the cutoff values of NLR were 3.872 at 3-month follow-up and 3.180 at 12-month follow-up. For poor functional outcomes, the cutoff value of NLR was 2.846 at both 3- and 12-month follow-ups. The association between NLR and stroke recurrence was significant only at 3-month follow-up before adjustments. There was no correlation between NLR and hemorrhagic transformation during hospitalization. Under different TOAST classifications, the medians of NLR were different; conversely, the correlations of NLR with adverse clinical outcomes had no differences.